The oxidation of 1??alkyl (aryl) quinolinium chlorides with rabbit liver aldehyde oxidase

…, BH Van Valkengoed, DJ Buurman…

Index: Angelino, S. A. F. G.; Valkengoed, B. H. van; Buurman, D. J.; Plas, H. C. van der; Mueller, F. Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 107 - 112

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Citation Number: 12

Abstract

Abstract 1-Alkyl (aryl) quinolinium chlorides are oxidized by rabbit liver aldehyde oxidase at positions C-2 and C-4. The site and the maximum rate of oxidation are dependent on the size and the steric conformation of the N-1 substituent. The presence of a 3-carboxamido group directs the oxidation completely to position C-4, irrespective of the size of the N- substituent. Application of covalent amination in liquid ammonia as an “enzyme model” for ...