Modification of the side chain of micromolide, an anti-tuberculosis natural product

…, R He, B Wan, Y Wang, GF Pauli, SG Franzblau…

Index: Yuan, Hai; He, Rong; Wan, Baojie; Wang, Yuehong; Pauli, Guido F.; Franzblau, Scott G.; Kozikowski, Alan P. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5311 - 5315

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Citation Number: 10

Abstract

This paper describes a series of modifications of the side chain of micromolide, an anti- tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.