Palladium (0)-catalyzed heteroarylation of 2-and 3-indolylzinc derivatives. An efficient general method for the preparation of (2-pyridyl) indoles and their application to …

…, S Hadida, G Pshenichnyi, J Bosch

Index: Amat, Mercedes; Hadida, Sabine; Pshenichnyi, Grigorii; Bosch, Joan Journal of Organic Chemistry, 1997 , vol. 62, # 10 p. 3158 - 3175

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Citation Number: 112

Abstract

Palladium (0)-catalyzed coupling of (1-(benzenesulfonyl)-2-indolyl) zinc chloride (1) and (1- (tert-butyldimethylsilyl)-3-indolyl) zinc chloride (6) with diversely substituted (alkyl, methoxy, methoxycarbonyl, nitro, hydroxy) 2-halopyridines gives the corresponding 2-and 3-(2- pyridyl) indoles [4 and 7 (or 8), respectively] in excellent yields. A series of other 3- (heteroaryl) indoles (pyrazinyl, furyl, thienyl, indolyl) have been similarly prepared from 6. ...