Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5 (4H)-ones via efficient cross-Claisen condensation

RV Ragavan, V Vijayakumar, NS Kumari

Index: Venkat Ragavan; Vijayakumar; Suchetha Kumari European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 3852 - 3857

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Citation Number: 79

Abstract

α-Oxy/thio substituted-β-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5 (4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.