Improved process for the preparation of montelukast: Development of an efficient synthesis, identification of critical impurities and degradants

…, J Jirman, O Boušková, P Gibala…

Index: Dufresne, Claude; Gallant, Michel; Gareau, Yves; Ruel, Rejean; Trimble, Laird; Labelle, Marc Journal of Organic Chemistry, 1996 ,  vol. 61,  # 24  p. 8518 - 8525

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Citation Number: 15

Abstract

... Select a Journal or Book ... a salt of montelukast 1 with an alkali metal and several undesired impurities dissolved together in organic solvents used. ... well-crystallizing salts with amines, followed by recrystallization of these salts with simultaneous removal of chemical impurities ...