Steroids

Synthesis of 3α, 7α-dihydroxy-5β-cholestan-26-oic acid from 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid: configuration in the bile of Alligator mississippiensis

AK Batta, R Mirchandani, G Salen, S Shefer

Index: Batta, Ashok K.; Mirchandani, Renu; Salen, Gerald; Shefer, Sarah Steroids, 1992 ,  vol. 57,  # 4  p. 162 - 166

Full Text: HTML

Citation Number: 3

Abstract

Abstract Synthesis of 25R-and 25S-diastereoisomers of 3α, 7α-dihydroxy-5β-cholestan-26- oic acid from 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid is described. The 25S- diastereoisomer of 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid was obtained by vigorous hydrolysis of the bile of Alligator mississippiensis followed by repeated crystallization of the hydrolysate, and the 25R-diastereoisomer was isolated by hydrolysis ...