The 2, 5-diarylpyrroles are generally synthesized by following the classical PaalrKnorr synthesis involving the reaction of 1, 4-diketone with amines. 1 Some of the shortcomings in this reaction were overcome by a later method reported by McEwen. 2 Other methods available for pyrrole synthesis are Hantzsch synthesis using chloroacetone and 3-amino ethyl crotonate, 3 1, 3-dipolar cycloaddition reactions involving azalactones, oxazolones, ...
