The Journal of organic chemistry

Synthesis of 3, 5-disubstituted pyrazoles via cope-type hydroamination of 1, 3-dialkynes

L Wang, X Yu, X Feng, M Bao

Index: Wang, Liangguang; Yu, Xiaoqiang; Feng, Xiujuan; Bao, Ming Journal of Organic Chemistry, 2013 , vol. 78, # 4 p. 1693 - 1698

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Citation Number: 27

Abstract

An efficient method for the synthesis of 3, 5-disubstituted pyrazoles is described. The reactions of 1, 3-dialkynes with hydrazine proceeded smoothly in dimethyl sulfoxide under mild reaction conditions to produce 3, 5-disubstituted pyrazoles in satisfactory to excellent yields. A one-pot procedure of the transformation has been developed.

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