RSC Advances

… -and cinnamylboronic acid esters: efficient method for incorporation of positron-emitting 11 C radionuclide into organic frameworks by coupling between two sp 3- …

…, R Ijuin, J Son, Y Hatta, M Ohta, M Wakao, T Hosoya…

Index: Koyama, Hiroko; Zhang, Zhouen; Ijuin, Ryosuke; Siqin; Son, Jeongwan; Hatta, Yuma; Ohta, Masashi; Wakao, Masahiro; Hosoya, Takamitsu; Doi, Hisashi; Suzuki, Masaaki RSC Advances, 2013 , vol. 3, # 24 p. 9391 - 9401

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Citation Number: 4

Abstract

Pd0-mediated rapid cross coupling between sp3-hybridized carbons of CH3I and benzyl-or cinnamylboronic acid esters using [Pd {P (tert-C4H9) 3} 2]/CsF in DMF/H2O gave the corresponding methylated compounds in high yield. The utility was well demonstrated for the synthesis of short-lived PET tracer, N-(4-[11C] ethylphenyl) propionamide, in 90±1% radio-HPLC analytical yield and 49±3% radiochemical yield.