New Synthesis of Furans: the Rhodium??Catalysed Carbonylative Addition of Arylboronic Acids to Propargylic Alcohols/Cyclisation Sequence

J Dheur, M Sauthier, Y Castanet…

Index: Dheur, Julien; Sauthier, Mathieu; Castanet, Yves; Mortreuxa, Andre Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 557 - 561

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Citation Number: 21

Abstract

Abstract The rhodium-catalysed carbonylative addition of arylboronic acids to propargylic alcohols yields gamma-hydroxy enones that are readily cyclised through a dehydration step to the corresponding furan analogues. The transformation was improved thanks to the screening of the reaction conditions and consequent improvements were obtained from the use of dicarbonylrhodium iodide [Rh (CO) 2 I] 2 as catalyst precursor. The generalisation ...