Cross-metathesis of unsaturated α-amino acid derivatives

SCG Biagini, SE GibsonéThomas…

Index: Biagini, Stefano C. G.; Gibson, Susan E.; Keen, Stephen P. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 16 p. 2485 - 2499

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Citation Number: 63

Abstract

Cross-metathesis of homoallylglycine derivatives with aryl-and alkyl-substituted alkenes using the ruthenium catalyst (Cy3P) 2Cl2RuCHPh 1 has been achieved in 43–55 and 55– 66% yield respectively. Allylglycine, vinylglycine and dehydroalanine derivatives have also been examined. Whilst cross-metathesis of allylglycine derivatives with alkyl-substituted alkenes using catalyst 1 may be regarded as a synthetically useful procedure, cross- ...

~10%

~85%

~73%

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