Tetrahedron Letters

First total synthesis of haplacutine C

N Kutsumura, K Numata, T Saito

Index: Kutsumura, Noriki; Kubokawa, Keisuke; Saito, Takao Synlett, 2010 , # 18 p. 2717 - 2720

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Abstract

Abstract A total synthesis of haplacutine C has been achieved. The synthetic key features were the intramolecular aldol condensation for construction of the 4-quinolinone skeleton and the Stille coupling for elongation of the dienol side chain. In addition, the 4-O-protected-