A convergent synthesis of AR-C123196 utilising reaction between a cyclic carbonate and a phenol for aryl alkyl ether formation

GL Allsop, AJ Cole, ME Giles, E Merifield…

Index: Organic Process Research and Development, , vol. 13, # 4 p. 751 - 759

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Citation Number: 11

Abstract

... Organic Process Research & Development. ... During development, it became apparent that homocoupling of the boronic acid was occurring as a significant side reaction ... facile Pd(II)-mediated process, in accord with recent literature.(18) Several aspects of the process were fixed ...

~8%

Discovery of Potent, Selective, and Orally Active Carboxylic...

[Monovich, Lauren G.; Tommasi, Ruben A.; Fujimoto, Roger A.; Blancuzzi, Vincent; Clark, Kirk; Cornell, Wendy D.; Doti, Robert; Doughty, John; Fang, James; Farley, David; Fitt, John; Ganu, Vishwas; Goldberg, Ronald; Goldstein, Robert; Lavoie, Stacey; Kulathila, Raviraj; Macchia, William; Parker, David T.; Melton, Richard; O'Byrne, Elizabeth; Pastor, Gary; Pellas, Theodore; Quadros, Elizabeth; Reel, Noela; Roland, Dennis M.; Sakane, Yumi; Singh, Hem; Skiles, Jerry; Somers, Joseph; Toscano, Karen; Wigg, Andrew; Zhou, Siyuan; Zhu, Lijuan; Shieh, Wen-Chung; Xue, Song; McQuire, Leslie W. Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3523 - 3538]

The synthesis of hydroxyphenylthiophenes

[Baldwin, Larry J.; Pakray, Sudabeh; Castle, Raymond N.; Lee, Milton L. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1667 - 1669]

Structural and solvent/electrolyte effects on the selectivit...

[Capparelli, Michael P.; DeSchepper, Richard E.; Swenton, John S. Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 4953 - 4961]

The synthesis and characterisation of a novel thiophene-base...

[Journal of Materials Chemistry, , vol. 6, # 12 p. 1871 - 1878]

The synthesis of hydroxyphenylthiophenes

[Journal of Heterocyclic Chemistry, , vol. 22, p. 1667 - 1669]