Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy

…, F El Bahhaj, E Baucher, F Collette, V Héroguez…

Index: Delatouche, Regis; Denis, Iza; Grinda, Marion; Bahhaj, Fatima El; Baucher, Estelle; Collette, Floraine; Heroguez, Valerie; Gregoire, Marc; Blanquart, Christophe; Bertrand, Philippe European Journal of Pharmaceutics and Biopharmaceutics, 2013 , vol. 85, # 3 PART B p. 862 - 872

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Citation Number: 8

Abstract

Abstract The aim of this study was to develop clickable prodrugs bearing a tunable pH responsive linker designed for acidic pH-mediated release of histone deacetylase inhibitors. HDACi are an important class of molecules belonging to the epigenetic modulators used for innovative cancer strategies. The behavior of these prodrugs was determined by a bioluminescence resonance energy transfer assay in living tumor cells. This work ...