Intramolecular friedel-crafts alkylations. II. An efficient synthesis of biologically active 1, 2, 3, 4-tetrahydroisoquinolines

WL Mendelson, CB Spainhour, SS Jones, BL Lam…

Index: Mendelson, W. L.; Spainhour, C. B.; Jones, S. S.; Lam, B. L.; Wert, K. L. Tetrahedron Letters, 1980 , vol. 21, p. 1393 - 1396

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Citation Number: 21

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A new synthesis of tetrahydroisoquinolines bearing electron withdrawing groups is presented. The scope and mechanism of the reaction are discussed. Many of these tetrahydroisoquinolines are potent inhibitors of the enzyme PNMT. ... RD Topsom, personal communication to WL ...