Synlett

Desulfurizing Difluorination Reaction of Benzyl Sulfides Using IF5

T Fukuhara, S Hara

Index: Fukuhara, Tadahito; Hara, Shoji Synlett, 2009 , # 2 p. 198 - 200

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Citation Number: 7

Abstract

Previously, we reported the novel polyfluorination reaction of aryl alkyl sulfides using IF 5 with concomitant migration of the arylthio group. [7] During the study of fluorination of the sulfides using IF 5 , we found that in the reaction of benzyl sulfides 1 with IF 5 , a Pummerer-type fluorination and a desulfurizing fluorination reaction occur successively to give gem-difluoro compounds 2 selectively (Scheme [¹] ). ... The reaction of ethyl 2-methylthio-2-phenyl acetate (1a) ...