Total Syntheses of the Actin??Binding Macrolides Latrunculin A, B, C, M, S and 16??epi??Latrunculin B

…, L Turet, MDB Fenster, L Parra??Rapado…

Index: Fuerstner, Alois; De Souza, Dominic; Turet, Laurent; Fenster, Michael D. B.; Parra-Rapado, Liliana; Wirtz, Conny; Mynott, Richard; Lehmann, Christian W. Chemistry - A European Journal, 2007 , vol. 13, # 1 p. 115 - 134

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Citation Number: 85

Abstract

Abstract The latrunculins are highly selective actin-binding marine natural products and as such play an important role as probe molecules for chemical biology. A short, concise and largely catalysis-based approach to this family of bioactive macrolides is presented. Specifically, the macrocyclic skeletons of the targets were forged by ring-closing alkyne metathesis (RCAM) or enyne–yne metathesis of suitable diyne or enyne–yne precursors, ...