Organic letters

Rearrangement Strategy for the Synthesis of 2-Aminoanilines

A Porzelle, MD Woodrow, NCO Tomkinson

Index: Porzelle, Achim; Woodrow, Michael D.; Tomkinson, Nicholas C.O. Organic Letters, 2010 , vol. 12, # 7 p. 1492 - 1495

Full Text: HTML

Citation Number: 10

Abstract

Treatment of N-aryl hydroxylamines with trichloroacetonitrile in the presence of imidazole provides a simple and effective method for the preparation of synthetically versatile 2- aminoanilines. Reactions proceed in DMF at 40° C, providing the products in up to 86% isolated yield.