Pyrimidine acyclic nucleosides. 1-[(2-Hydroxyethoxy) methyl] pyrimidines as candidate antivirals

…, WR Hall, MP Krochmal, HJ Schaeffer

Index: Kelley, James L.; Kelsey, John E.; Hall, William R.; Krochmal, Mark P.; Schaeffer, Howard J. Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 753 - 756

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Citation Number: 55

Abstract

A number of pyrimidine acyclic nucleosides were synthesized and tested for activity against herpes simplex virus type 1. Synthesis of 1-[(2-hydroxyethoxy) methyl] cytosine (8) and 1-[(2- hydroxyethoxy) methyl] uracil (14) was accomplished in two or three steps from 2, 4- diethoxypyrimidine and 2-(benzoy1oxy) ethoxymethyl chloride. The &methyl (20), & (trifluoromethyl)(21), and 5fluoro (22) analogues of 14 were available in two steps from the ...