Antihypertensive (2-aminoethyl) thiourea derivatives. 1

…, P Levitan, RW Kierstead, M Cohen

Index: Tilley. Jefferson W.; Levitan, Paul; Kierstead, Richard W.; Cohen, Michael Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1387 - 1392

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Citation Number: 18

Abstract

Structure-activity studies were carried out on a series of antihypertensive l-(2-aminoethyl)-3- (substituted pheny1) thioureas. From this class of compounds, the 2, 6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog. In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.