Synthesis of fused polycycles by 1, 4-palladium migration chemistry

Q Huang, MA Campo, T Yao, Q Tian…

Index: Huang, Qinhua; Campo, Marino A.; Yao, Tuanli; Tian, Qingping; Larock, Richard C. Journal of Organic Chemistry, 2004 , vol. 69, # 24 p. 8251 - 8257

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Citation Number: 76

Abstract

Novel palladium migration/arylation methodology for the synthesis of complex fused polycycles has been developed, in which one or more sequential Pd-catalyzed intramolecular migration processes involving CH activation are employed. The chemistry works best with electron-rich aromatics, which is in agreement with the idea that these palladium-catalyzed CH activation reactions parallel electrophilic aromatic substitution.