Tetrahedron letters

Catalytic osmylation of allenic compounds. Synthesis of α-hydroxyketo amino acid precursors

K David, C Ariente, A Greiner, J Goré, B Cazes

Index: David, Katerine; Ariente, Cecile; Greiner, Alfred; Gore, Jacques; Cazes, Bernard Tetrahedron Letters, 1996 , vol. 37, # 19 p. 3335 - 3338

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Citation Number: 7

Abstract

Osmium tetroxyde-catalyzed dihydroxylation of allenic compounds in the presence of N- Methylmorpholine Oxide leads to α-ketols. Regioselectivity of this oxidation procedure with allenic α-amino acid precursors is greatly influenced by the nature and the remoteness of the protected amino acid group.