e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Structure–activity relationship (SAR) optimization of 6-(indol-2-yl) pyridine-3-sulfonamides: Identification of potent, selective, and orally bioavailable small molecules …

N Zhang, X Zhang, J Zhu, A Turpoff…

Index: Journal of Medicinal Chemistry, , vol. 57, # 5 p. 2121 - 2135

Full Text: HTML

Citation Number: 15

Abstract

... Journal of Medicinal Chemistry. ... J. Med. Chem. , 2014, 57 (5), pp 2121–2135. DOI: 10.1021/jm401621g. Publication Date (Web): November 22, 2013. Copyright © 2013 American Chemical Society. *Phone: +1-9089129238. E-mail: nzhang@ptcbio.com. ...

TERT-BUTYL 6-METHYL-1H-INDOLE-1-CARBOXYLATE Structure

TERT-BUTYL 6-ME...

~%

[1-(tert-butoxycarbonyl)-6-methyl-1H-indol-2-yl]boronic acid Structure

[1-(tert-butoxy...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

[1-(tert-butoxycarbonyl)-6-methyl-1H-indol-2-yl]boronic acid Structure

[1-(tert-butoxy...

6-Methyl-1H-indole Structure

6-Methyl-1H-indole

~%

[1-(tert-butoxycarbonyl)-6-methyl-1H-indol-2-yl]boronic acid Structure

[1-(tert-butoxy...

Structure–activity relationship (SAR) optimization of 6-(ind...

[Zhang, Nanjing; Zhang, Xiaoyan; Zhu, Jin; Turpoff, Anthony; Chen, Guangming; Morrill, Christie; Huang, Song; Lennox, William; Kakarla, Ramesh; Liu, Ronggang; Li, Chunshi; Ren, Hongyu; Almstead, Neil; Venkatraman, Srikanth; Njoroge, F. George; Gu, Zhengxian; Clausen, Valerie; Graci, Jason; Jung, Stephen P.; Zheng, Yingcong; Colacino, Joseph M.; Lahser, Fred; Sheedy, Josephine; Mollin, Anna; Weetall, Marla; Nomeir, Amin; Karp, Gary M. Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 2121 - 2135]

Structure–activity relationship (SAR) optimization of 6-(ind...

[Zhang, Nanjing; Zhang, Xiaoyan; Zhu, Jin; Turpoff, Anthony; Chen, Guangming; Morrill, Christie; Huang, Song; Lennox, William; Kakarla, Ramesh; Liu, Ronggang; Li, Chunshi; Ren, Hongyu; Almstead, Neil; Venkatraman, Srikanth; Njoroge, F. George; Gu, Zhengxian; Clausen, Valerie; Graci, Jason; Jung, Stephen P.; Zheng, Yingcong; Colacino, Joseph M.; Lahser, Fred; Sheedy, Josephine; Mollin, Anna; Weetall, Marla; Nomeir, Amin; Karp, Gary M. Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 2121 - 2135]

Structure–activity relationship (SAR) optimization of 6-(ind...

[Zhang, Nanjing; Zhang, Xiaoyan; Zhu, Jin; Turpoff, Anthony; Chen, Guangming; Morrill, Christie; Huang, Song; Lennox, William; Kakarla, Ramesh; Liu, Ronggang; Li, Chunshi; Ren, Hongyu; Almstead, Neil; Venkatraman, Srikanth; Njoroge, F. George; Gu, Zhengxian; Clausen, Valerie; Graci, Jason; Jung, Stephen P.; Zheng, Yingcong; Colacino, Joseph M.; Lahser, Fred; Sheedy, Josephine; Mollin, Anna; Weetall, Marla; Nomeir, Amin; Karp, Gary M. Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 2121 - 2135]