Tetrahedron Letters

Direct access to 3-substituted 1, 4-oxathiepino [5, 6-b] pyridine-5-one through one-pot substitution cyclization reaction of 2-mercapto-3-nicotinic acid with α-bromo …

S Singh, A Schober, GA Gross

Index: Singh, Sukhdeep; Schober, Andreas; Gross, G. Alexander Tetrahedron Letters, 2014 , vol. 55, # 2 p. 358 - 361

Full Text: HTML

Citation Number: 1

Abstract

Abstract A direct, one-pot synthesis route to [1, 4] oxathiepino [5, 6-b] pyridin-5-one derivatives was optimized by reacting different α-bromo ketones with 2-mercaptonicotinic acid. The advantages of this method include high efficiency, regioselective, and multistep conversion in a single-pot protocol. These types of pyridine annulated [1, 4] oxathiepin-5- one derivatives are described here for the first time and seem to be interesting candidates ...