Synlett

A highly efficient approach for the synthesis of cationic lipid DOSPA

Y Li, RJ Debs, TD Heath

Index: Li, Yanhong; Debs, Robert J.; Heath, Timothy D. Synlett, 2006 , # 14 p. 2284 - 2286

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Abstract

Abstract A highly efficient strategy has been developed for the synthesis of the cationic lipid, N-[2-({2, 5-bis [(3-aminopropyl) amino]-1-oxopentyl} amino) ethyl]-N, N-dimethyl-2, 3-bis [(1- oxo-9-octadecenyl) oxy] salt with hydrogen chloride (DOSPA). It involves the linkage of a cationic head group and a hydrophobic moiety in the presence of the standard coupling reagents.