Tetrahedron letters

An efficient copper-catalyzed coupling of aryl halides with imidazoles

A Kiyomori, JF Marcoux, SL Buchwald

Index: Kiyomori, Ayumu; Marcoux, Jean-Francois; Buchwald, Stephen L. Tetrahedron Letters, 1999 , vol. 40, # 14 p. 2657 - 2660

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Citation Number: 365

Abstract

Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf) 2· benzene as a copper source and Cs2CO3 as a base in xylenes at 110–125° C. Addition of 1, 10- phenanthroline (phen) and trans, trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylimidazoles, were isolated in high yields.