Il Farmaco

Quinoxaline chemistry. Part 15. 4-[2-Quinoxalylmethylenimino]-benzoylglutamates and-benzoates, 4-[2-quinoxalylmethyl-N-methylamino]-benzoylglutamates as …

M Loriga, S Piras, G Paglietti, MP Costi, A Venturelli

Index: Loriga, Mario; Piras, Sandra; Paglietti, Giuseppe; Costi, Maria Paola; Venturelli, Alberto Farmaco, 2003 , vol. 58, # 1 p. 51 - 61

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Citation Number: 25

Abstract

We report on an extension of our previous discovery of in vitro anticancer activity of trifluoromethylquinoxalines as analogues of classical and non-classical antifolic methotrexate and trimetrexate. In this case a small number of Schiff bases were obtained from the reaction of 2-bromethyl-3-R-6 (7) trifluoromethylquinoxaline and ethyl p- aminobenzoylglutamate, ethyl p-aminobenzoate, p-toluidine instead of the expected 4-[2- ...