A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor

…, E Baxter, IB Campbell, SJF Macdonald

Index: Wheeler, Rob C.; Baxter, Emma; Campbell, Ian B.; MacDonald, Simon J. F. Organic Process Research and Development, 2011 , vol. 15, # 3 p. 565 - 569

Full Text: HTML

Citation Number: 21

Abstract

Flow chemistry is a rapidly emerging technology within the pharmaceutical industry, both within medicinal and development chemistry groups. The advantages of flow chemistry, increased safety, improved reproducibility, enhanced scalability, are readily apparent, and ...

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monomethylhydrazine Structure

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monomethylhydrazine

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1-Methyl-1H-pyrazolo[3,4-b]pyridin-3-amine Structure

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2-Fluoro-5-nitrobenzaldehyde Structure

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Benzylhydrazine Structure

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Benzylhydrazine

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1-BENZYL-5-NITRO-1H-INDAZOLE Structure

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monomethylhydrazine Structure

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monomethylhydrazine

Methyl 4-bromo-2-fluorobenzoate Structure

179232-29-2

Methyl 4-bromo-...

~70%

6-Bromo-1-methyl-1H-indazol-3(2H)-one Structure

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6-Bromo-1-methy...

4-Bromo-2-fluorobenzoic acid Structure

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4-Bromo-2-fluor...

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6-Bromo-1-methyl-1H-indazol-3(2H)-one Structure

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6-Bromo-1-methy...

monomethylhydrazine Structure

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monomethylhydrazine

4-Bromo-2-fluorobenzaldehyde Structure

57848-46-1

4-Bromo-2-fluor...

~49%

6-Bromo-1-methyl-1H-idazole Structure

590417-94-0

6-Bromo-1-methy...

2-Fluoro-5-nitrobenzaldehyde Structure

27996-87-8

2-Fluoro-5-nitr...

~70%

5-Nitro-1H-indazole Structure

5401-94-5

5-Nitro-1H-indazole

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446-26-4

Methyl 2-fluoro...

monomethylhydrazine Structure

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monomethylhydrazine

~58%

1-methyl-2H-pyrazolo[3,4-b]pyridin-3-one Structure

2942-45-2

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2-Fluoro-4-nitrobenzonitrile Structure

34667-88-4

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monomethylhydrazine Structure

60-34-4

monomethylhydrazine

~63%

1-Methyl-6-nitro-1H-indazol-3-amine Structure

77894-88-3

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2-Fluorobenzaldehyde Structure

446-52-6

2-Fluorobenzaldehyde

monomethylhydrazine Structure

60-34-4

monomethylhydrazine

~40%

1H-Indazole,1-methyl- Structure

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2-Fluoro-4-nitrobenzonitrile Structure

34667-88-4

2-Fluoro-4-nitr...

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6-Nitro-1H-indazol-3-amine Structure

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6-Nitro-1H-inda...

4-Bromo-2-fluorobenzonitrile Structure

105942-08-3

4-Bromo-2-fluor...

monomethylhydrazine Structure

60-34-4

monomethylhydrazine

~60%

6-bromo-1-methyl-1H-indazol-3-amine Structure

1214899-85-0

6-bromo-1-methy...

2-Fluoro-4-methylbenzaldehyde Structure

146137-80-6

2-Fluoro-4-meth...

monomethylhydrazine Structure

60-34-4

monomethylhydrazine

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1,6-Dimethyl-1H-indazole Structure

34879-87-3

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1-(2-Fluorophenyl)ethanone Structure

445-27-2

1-(2-Fluorophen...

monomethylhydrazine Structure

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