Synthesis of 3-phenylpyrazolopyrimidine-1, 2, 3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities

…, I Ahmad, BS Chhikara, R Tiwari, D Mandal…

Index: Kumar, Anil; Ahmad, Israr; Chhikara, Bhupender S.; Tiwari, Rakesh; Mandal, Deendayal; Parang, Keykavous Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1342 - 1346

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Citation Number: 54

Abstract

A series of two classes of 3-phenylpyrazolopyrimidine-1, 2, 3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB- 361), and colon adenocarcinoma (HT-29). Hexyl triazolyl-substituted 3- phenylpyrazolopyrimidine exhibited inhibition of Src kinase with an IC50 value of 5.6 μM. ...