Tetrahedron letters

Fragmentation during the formic acid/formaldehyde (eschweiler-clarke) methylation of polyamines

RW Alder, D Colclough, RW Mowlam

Index: Alder, Roger W.; Colclough, David; Mowlam, Rodney W. Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7755 - 7758

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Citation Number: 15

Abstract

Abstract Eschweiler-Clarke methylations of both acyclic and cyclic polyamines can lead to methylation products of fragments of the original polyamine; thus 1, 5, 9, 13-tetra- azatridecane yields 1, 1, 3, 3-tetramethylpropanediamine exclusively and 1, 5, 9- triazacyclododecane gives 45% 1, 5, 9-trimethyl-1, 5, 9-triazacyclodecane and 45% 2, 6, 10- trimethyl-2, 6, 10-triazaundecane.