Convenient access to 1, 3, 4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1, 3-dipolar cycloaddition of sydnones with acetylenic ketones and their …

NS Rai, B Kalluraya, B Lingappa, S Shenoy…

Index: Satheesha Rai; Kalluraya, Balakrishna; Lingappa; Shenoy, Shaliny; Puranic, Vedavati G. European Journal of Medicinal Chemistry, 2008 , vol. 43, # 8 p. 1715 - 1720

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Citation Number: 127

Abstract

Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1, 3- dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies ...