Heterocyclic quinones. 4. A new highly cytotoxic drug: 6, 7-bis (1-aziridinyl)-5, 8-quinazolinedione

…, S Giorgi-Renault, M Baron, P Mailliet…

Index: Renault, Jean; Giorgi-Renault, Sylviane; Baron, Michel; Mailliet, Patrick; Paoletti, Claude; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1715 - 1719

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Citation Number: 16

Abstract

With the aim of obtaining new antitumoral agents, a series of 5, 8-quinazolinediones was prepared. 5-Amino-6-methoxyquinazoline was oxidized by Fremy's salt to give 6-methoxy-5, 8-quinazolinedione. Nucleophilic substitution reaction at C6, electrophilic substitution at C7, and synthesis of 7-amino-6-methoxy-5, 8-quinazolinedione, the parent compound of streptonigrin, were studied. These compounds were tested for cytotoxic properties on ...