Facile synthesis of functionalized 4-aminopyridines

N Nishiwaki, M Azuma, M Tamura, K Hori…

Index: Nishiwaki, Nagatoshi; Azuma, Mayumi; Tamura, Mina; Hori, Kazushige; Tohda, Yasuo; Ariga, Masahiro Chemical Communications, 2002 , # 18 p. 2170 - 2171

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Citation Number: 9

Abstract

4-Aminopyridine-3-carboxylic acid (4-aminonicotinic acid) and its ester are sometimes found as a partial structure in natural products, 1 and their derivatives behave as NAD analogs. 2 4-Aminopyridines (4APs) having a functional group at the vicinal position are also excellent precursors for [c]-fused pyrido compounds such as pyridopyrimidine, imidazopyridine, pyrazolopyridine and naphthyridine, those are widely used for medicines or their synthetic intermediates. 3 ...