Tetrahedron letters

An efficient synthesis of novel 1, 3-oxazolo [4, 5-d] pyridazinones

EB Frolov, FJ Lakner, AV Khvat, AV Ivachtchenko

Index: Frolov, Eugene B.; Lakner, Frederick J.; Khvat, Alexandre V.; Ivachtchenko, Alexandre V. Tetrahedron Letters, 2004 , vol. 45, # 24 p. 4693 - 4696

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Citation Number: 30

Abstract

A convenient and versatile synthetic approach to substituted 1, 3-oxazolo [4, 5-d] pyridazinones is developed. The oxazole ring was formed upon reaction of 5-amino-4- hydroxy-3 (2H)-pyridazinone with various carboxylic acid derivatives using a microwave- assisted procedure, which favors the reaction time and purity of the resulting products. The developed methodology is suitable for rapid, parallel, automated synthesis of ...