Synthesis and reactions of some new quinoline thiosemicarbazide derivatives of potential biological activity

EM Keshk, SI El-Desoky, MAA Hammouda…

Index: Keshk; El-Desoky; Hammouda; Abdel-Rahman; Hegazi Phosphorus, Sulfur and Silicon and the Related Elements, 2008 , vol. 183, # 6 p. 1323 - 1343

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Citation Number: 15

Abstract

Quinoline-2-carbohydrazide (3) was reacted with aryl or alkyl isothiocyanates to give the corresponding quinoline thiosemicarbazides (4a–e). Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of 5-(quinolin-2-yl)-2H-1, 2, 4- triazole-3 (4H)-thiones (5a–e). Desulfurization of thiosemicarbazides by mercuric oxide gave 5-(quinolin-2-yl)-1, 3, 4-oxadiazol-2-amines (6a–e). Treatment of thiosemicarbazides with ...

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Quinazolines

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