Chemistry letters

Mild and Efficient α-Chlorination of Carbonyl Compounds Using Ammonium Chloride and Oxone (2KHSO 5· KHSO 4· K 2 SO 4)

P Swamy, MA Kumar, MM Reddy, N Narender

Index: Swamy, Peraka; Kumar, MacHarla Arun; Reddy, Marri Mahender; Narender, Nama Chemistry Letters, 2012 , vol. 41, # 4 p. 432 - 434

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Citation Number: 12

Abstract

A simple protocol for the α-monochlorination of ketones and 1, 3-dicarbonyl compounds utilizing NH 4 Cl as a source of chlorine and Oxone as an oxidant in methanol without catalyst is presented. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent.