Angewandte Chemie International Edition

The Heck Reaction of Electron??Rich Olefins with Regiocontrol by Hydrogen??Bond Donors

J Mo, J Xiao

Index: Mo, Jun; Xiao, Jianliang Angewandte Chemie - International Edition, 2006 , vol. 45, # 25 p. 4152 - 4157

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Citation Number: 94

Abstract

important conclusion then is that the HBr generated from each arylation cycle must be effectively scavenged by NEt3, as the reaction would otherwise be practically stopped before reaching an approximate conversion of 25%. The trapping of the bromide anions could be brought about by possible hydrogen bonding between [HNEt3]+ and BrÀ, thus rendering the equilibrium in favor of the right side [Eq.(2)]. Hydrogen bonding is indicated ...