Electrophile Aminierung von C??H??aciden Verbindungen mit 1??Oxa??2??azaspiro [2.5] octan

S Andreae, E Schmitz, JP Wulf…

Index: Andreae, Siegfried; Schmitz, Ernst; Wulf, Jens-Peter; Schulz, Burkhard Liebigs Annalen der Chemie, 1992 , # 3 p. 239 - 256

Full Text: HTML

Citation Number: 0

Abstract

5 (4H)-one, and phenylbutazone (33)] have been studied. After the introduction of a 1- hydroxycyclohexylamino group at the acidic position, five different stabilisation reactions of the intermediate 2 could be classified. The most important one is an intramolecular nucleophilic attack to a nitrile group giving disubstituted 1, 4-diazaspiro [4.5] decanones 2a. Their ring transformations (eg 2a+ 3) or the introduction of a second amino group at the ...