Synthesis and in vitro anticancer activities of some selenadiazole derivatives

…, M Font, I Encio, JA Palop, C Sanmartin

Index: Plano, Daniel; Moreno, Esther; Font, Maria; Encio, Ignacio; Palop, Juan Antonio; Sanmartin, Carmen Archiv der Pharmazie, 2010 , vol. 343, # 11-12 p. 680 - 691

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Citation Number: 41

Abstract

Abstract A novel series of fourteen substituted selenadiazoles has been synthesized and the compounds tested for their in vitro antiproliferative and cytotoxic activities. The tests were carried out against leukemia (CCRF-CEM), colon (HT-29), lung (HTB-54), and breast (MCF- 7) cancer cells. In order to assess the selectivity of the compounds under investigation the assays were also carried out on two non-tumoral lines–one mammary (184B5) and one ...