One-pot concise syntheses of benzimidazo [2, 1-a] isoquinolines by a microwave-accelerated tandem process

N Okamoto, K Sakurai, M Ishikura, K Takeda…

Index: Okamoto, Noriko; Sakurai, Keisuke; Ishikura, Minoru; Takeda, Kei; Yanada, Reiko Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4167 - 4169

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Citation Number: 39

Abstract

Direct, efficient syntheses of the benzimidazo [2, 1-a] isoquinoline ring system have been achieved with 2-bromoarylaldehydes, terminal alkynes, and 1, 2-phenylenediamines by a microwave-accelerated tandem process in which a Sonogashira coupling, 5-endo cyclization, oxidative aromatization, and 6-endo cyclization can be performed in a single synthetic operation.