Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and cognitive decline. AD is the most common form of dementia and affects up to 50% of the population over 85 years of age. 1 The amyloid-β (Aβ) peptide is the major component of extracellular proteinaceous plaques found in Alzheimer's brains, and soluble Aβ has been shown to be neurotoxic in vitro. 2 Cleavage of amyloid precursor protein (APP) by both β- and γ- ...
[Hughes, Simon; Griffiths, Gwerydd; Stirling, Charles J. M. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 1253 - 1264]
