Aryl sulfones: a new class of γ-secretase inhibitors

…, T Harrison, D Shaw, E Kay, J Elliott, U Gerhard…

Index: Teall, Martin; Oakley, Paul; Harrison, Timothy; Shaw, Duncan; Kay, Euan; Elliott, Jason; Gerhard, Ute; Castro, Jose L.; Shearman, Mark; Ball, Richard G.; Tsou, Nancy N. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2685 - 2688

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Citation Number: 44

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and cognitive decline. AD is the most common form of dementia and affects up to 50% of the population over 85 years of age. 1 The amyloid-β (Aβ) peptide is the major component of extracellular proteinaceous plaques found in Alzheimer's brains, and soluble Aβ has been shown to be neurotoxic in vitro. 2 Cleavage of amyloid precursor protein (APP) by both β- and γ- ...