Novel bis (indolyl) hydrazide–hydrazones as potent cytotoxic agents

D Kumar, NM Kumar, S Ghosh, K Shah

Index: Kumar, Dalip; Maruthi Kumar; Ghosh, Soumitra; Shah, Kavita Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 212 - 215

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Citation Number: 47

Abstract

A series of bis (indolyl) hydrazide–hydrazones 5a–n were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3- carboxaldehyde 2 with indole-3-carbohydrazide 4 in presence of catalytic amount of acetic acid afforded 5a–n in good yields. Among the synthesized bis (indolyl) hydrazide– hydrazones, the compound 5b with N-(p-chlorobenzyl) and bromo substituents was found ...