Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity

J Roppe, ND Smith, D Huang, L Tehrani…

Index: Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4645 - 4648

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Citation Number: 113

Abstract

... Journal of Medicinal Chemistry. ... The chemical synthesis of the N-linked azole analogues is summarized in Schemes 1−3 (detailed procedures may be found in the Supporting Information). Yields reported are unoptimized. ...

Fragment-based discovery of 6-azaindazoles as inhibitors of ...

[Howard, Steven; Amin, Nader; Benowitz, Andrew B.; Chiarparin, Elisabetta; Cui, Haifeng; Deng, Xiaodong; Heightman, Tom D.; Holmes, David J.; Hopkins, Anna; Huang, Jianzhong; Jin, Qi; Kreatsoulas, Constantine; Martin, Agnes C. L.; Massey, Frances; McCloskey, Lynn; Mortenson, Paul N.; Pathuri, Puja; Tisi, Dominic; Williams, Pamela A. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 12 p. 1208 - 1212]