4, 6-Disubstituted 2, 2-dimethylchromans structurally related to the KATP channel opener cromakalim: design, synthesis, and effect on insulin release and vascular …

…, S Boverie, B Pirotte, P Lebrun

Index: Khelili; Nguyen; Lebrun; Delarge; Pirotte Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 3 p. 189 - 193

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Citation Number: 31

Abstract

Five series (ureas, thioureas, carbamates, sulfonylureas, and amides) of 4, 6-disubstituted-2, 2-dimethylchromans structurally related to cromakalim were prepared and evaluated, as putative ATP-sensitive potassium channel activators, on rat pancreatic islets and rat aorta