Tetrahedron letters

Claisen self-condensation/decarboxylation as the key steps in the synthesis of C 2-symmetrical 1, 7-dioxaspiro [5.5] undecanes

B Lastdrager, MSM Timmer, GA van der Marel…

Index: Lastdrager, Bas; Timmer, Mattie S. M.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S. Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6195 - 6198

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Citation Number: 8

Abstract

A convenient method for the synthesis of functionalised 1, 7-dioxaspiro [5.5] undecanes using acid-catalysed spiroketalisations of substituted dihydroxyketones is described. The dihydroxyketones were readily prepared from appropriately substituted hydroxy esters via Claisen self-condensation followed by decarboxylation.