Study on condensation of N??aryl thioureas with 3??bromo??acetylacetone: Synthesis of aminothiazoles and iminodihydrothiazoles, and their in vitro antiproliferative …

HB Shi, SJ Zhang, YF Lin, WX Hu…

Index: Shi, Hai-Bo; Zhang, Shi-Jie; Lin, Yan-Fang; Hu, Wei-Xiao; Cai, Chao-Ming Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1061 - 1066

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Citation Number: 5

Abstract

Abstract The condensation of N-aryl thioureas with 3-bromo-acetylacetone in neutral solvent acetone not only led to 5-acetyl-4-methyl-2-(substituted anilino) thiazoles 3 but also 2-imino- 3-(substituted phenyl)-4-methyl-5-acetyl-2, 3-dihydrothiazoles 4. Further study found that different reaction solvents displayed an important role toward the ratio of aminothiazoles 3 and iminodihydrothiazoles 4, and the reaction scope was extended. A plausible ...