Tetrahedron Letters

Access to the nicotine system by application of a guanidine-catalyzed asymmetric Michael addition of diphenyliminoacetate with 3-pyridyl vinyl ketone

G Zhang, T Kumamoto, T Heima, T Ishikawa

Index: Zhang, Gang; Kumamoto, Takuya; Heima, Takashi; Ishikawa, Tsutomu Tetrahedron Letters, 2010 , vol. 51, # 30 p. 3927 - 3930

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Citation Number: 15

Abstract

... Please enable JavaScript to use all the features on this page. Tetrahedron Letters. Volume 51, Issue 30, 28 July 2010, Pages 3927–3930. ... online 25 May 2010. Abstract. A guanidine-based chiral organocatalyst was successfully applied to the Michael addition of diphenyliminoacetate to pyridyl vinyl ketone as a key reaction for the construction of the nicotine system. ... For a review of syntheses of nicotine, its derivatives, see: Tetrahedron, 63 (2007), pp. 8065–8082. ...