Syntheses of (S)-(-)-3-piperidinol from L-glutamic acid and (S)-malic acid

…, KL Bhat, RB Wardle, WJ Hennen…

Index: Olsen, Richard K.; Bhat, Krishna L.; Wardle, Robert B.; Hennen, William J.; Kini, Ganesh D. Journal of Organic Chemistry, 1985 , vol. 50, # 6 p. 896 - 899

Full Text: HTML

Citation Number: 26

Abstract

7 1 chloropiperidine unit of S configuration, we were interested in synthetic routes to the chiral piperidinol 1 that could serve as a model for approaches to the piperidine moiety of the antibiotic. We have studied two routes to 1 that originated from L-glutamic acid and from@)-(-)-malic acid, two well-known substrates from the chiral pool. L-(+)-Glutamic acid (3) was converted into the known3