Tetrahedron

A novel one-pot synthesis of 2-arylpyrazoloquinolinone derivatives

EC Chang, YL Wen, CH Chang, YH Shen, SB Wen…

Index: Chang, En-Chiuan; Wen, Ya-Lan; Chang, Chun-Hsi; Shen, Yun-Hwei; Wen, Shaw-Bing; Yeh, Mou-Yung; Wong, Fung Fuh Tetrahedron, 2012 , vol. 68, # 29 p. 5920 - 5924

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Citation Number: 4

Abstract

Two regioisomers of 2-arylpyrazolo [3, 4-c] quinolin-4 (5H)-ones and 2-arylpyrazolo [4, 3-c] quinolin-4 (5H)-ones were synthesized by utilizing 3-arylsydnones, ethyl 3- bromopropynoate, and 2-aminophenylboronic acid pinacol ester in presence of catalytic agent Pd (PPh3) 4. This efficient one-pot synthesis methodology involved 1, 3-dipolar cycloaddition, Suzuki coupling reaction, and intramolecular cyclization three sequence ...