Synthesis and structure− activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains

…, I Kmentova, SG Franzblau, B Wan…

Index: Brown, Thomas B.; Lowe, Philip R.; Schwalbe, Carl H.; Stevens, Malcolm F.G. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2485 - 2490

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Citation Number: 45

Abstract

... Journal of Medicinal ... of the nitroimidazole ring,(7, 8) leading to the release of nitric oxide as a toxic species.(9) Both 1 and the related 6-nitroimidazo[2,1-b][1,3]oxazole ... 2,4,6-triBrPhN 3 , reflux, 5 h, then aq HCl, then CH 2 N 2 , Et 2 O, MeOH, 20 °C; (vii) LiAlH 4 , Et 2 O, 0 °C, 1 h. ...